5-LOX Inhibitor with AprèsFlex®

5-lipoxygenase (5-LOX) is an enzyme that transforms fatty acids into leukotrienes.¹ Since 5-LOX levels increase over time, excess 5-LOX has been linked to some of the common effects of normal aging.²

Boswellia extract inhibits 5-LOX

The Indian plant Boswellia serrata contains compounds shown to inhibit 5-LOX to support joint and arterial health. Boswellia inhibits 5-LOX at the cellular level. Scientific data reveals that a compound in boswellia called AKBA (3-O-acetyl-11-keto-ß-boswellic acid) is the key to this beneficial action.³

But boswellia compounds are poorly absorbed into the blood. For this reason, we’ve used AprèsFlex®, a standardized form of boswellia extract. AprèsFlex® absorbs into the blood 52% more than previously available boswellia extracts.⁴

Dietary factors increase 5-LOX prevalence

The typical American diet adds to 5-LOX levels. Foods rich in omega-6 fatty acids like red meat, poultry, eggs and dairy products, along with high-glycemic carbohydrates, trigger production of arachidonic acid. The body produces 5-LOX enzyme in response to arachidonic acid.¹

Benefits of modulating 5-LOX

5-LOX creates compounds like leukotriene B4 out of arachidonic acid. Inhibiting leukotriene B4 helps support joint, arterial and tissue health.⁵ Inhibiting 5-LOX also helped support healthy cell division in preclinical models.⁶

Each 100 mg vegetarian capsule of 5-LOX Inhibitor with AprèsFlex® is standardized to provide 20% of active AKBA from boswellia. Most people need only one capsule a day.

Reference

1. Biochim Biophys Acta - Molecular and Cell Biology of Lipids. 2015;1851(4):331-339.
2. Faseb j. 2000;14(10):1464-1469.
3. Clin Pharmacokinet.2011;50(6):349-369.
4. Mol Cell Biol.2011;354(1):189-197.
5. Semin Immunol.2017;33:3-15.
6. Clin Cancer Res.2005;11(5):2089.