SAMe (S-Adenosyl-Methionine)

S-adenosyl-methionine (SAMe), is made naturally by your body. It participates in many critical metabolic functions by donating methyl groups to other molecules. Methyl groups need to be transferred between compounds in the body to help with things like neurotransmitter signaling and protein function.^1,2

Mood, joint & liver health

SAMe helps maintain stable mood³ and joint comfort.⁴ It also supports liver health, which is not surprising since a large portion of the body's SAMe is made in the liver.⁵ But SAMe levels decline over time.⁶

SAMe supports your body's antioxidant defenses by donating sulfur molecules to help with the production of glutathione, one of the body's most important natural antioxidants.⁷

There is so much research on SAMe that the U.S. Department of Health and Human Services conducted a meticulous evaluation of the evidence. The analysis showed that SAMe has helped maintain stable mood and joint function in several studies.⁸

Supplementing with SAMe is one way to support the numerous bodily functions that depend on the fascinating biochemical properties of this vital molecule.

References

1. Am J Clin Nutr. 2002;76(5):1151s-7s.
2. Annu Rev Biochem. 2016;85:485-514.
3. J Clin Psychiatry. 2017;78(6):e656-e667.
4. Am J Med. 1987;83(5a):66-71.
5. Ann Hepatol. 2013;12(2):183-9.
6. J Gerontol. 1977;32(4):392-4.
7. Int J Biochem Cell Biol. 2000;32(4):391-5.
8. U.S. Department of Health and Human Services. S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease. Accessed May 23, 2019. https://archive.ahrq.gov/clinic/epcsums/samesum.htm