Scientists have identified four plant-derived compounds that support the body’s endocannabinoid system without CBD.
Scientifically reviewed by: Dr. Gary Gonzalez, MD, on October 2020. Written By Paul Johnson.
Scientists have discovered that the endocannabinoid system influences the balance and function of almost all bodily systems.
But as we age, the endocannabinoid system becomes less active.1,2 That can lead to accelerated aging and increased susceptibility to disease.1
Research has shown that the endocannabinoid system plays a profound role throughout the rest of the body, affecting everything from bone strength to fat and glucose metabolism.2
In the past years CBD (cannabidiol) products have become increasingly popular, ranging from a variety of formulations from oils to cosmetics.
This comes from the fact that CBD interacts with and supports the endocannabinoid system.
The problem is that there are many unanswered questions about the quality and efficacy of the CBD-containing products purchased commercially.
For those who want to improve their internal endocannabinoid functions, scientists have identified four plant compounds that favorably influence the endocannabinoid system in multiple ways.
Like hormones and nerve cells, the endocannabinoid system is a cellular communication system, allowing various cells to send signals to others.
It helps to regulate and maintain the optimal function of many bodily systems.
It also helps maintain homeostasis, stability in response to changes in the environment, throughout the body.
The endocannabinoid system is active in most tissues. It has been identified in brain, bone, muscle, liver, and fat tissue, immune cells, and more.1-3
It’s made up of three parts:
Two of the best-known endocannabinoids are anandamide (AEA) and 2-arachidonoyl glycerol (2-AG). They interact with receptors throughout the body.
The name “endocannabinoid” comes from the fact that plant-derived cannabinoid compounds, such as those found in cannabis, influence cannabinoid receptors on cell membranes. “Endo” refers to something formed within the body.
Unlike cannabinoids from cannabis, endocannabinoids do not have psychoactive effects. But they have a profound impact on the brain and body.
In the brain, the endocannabinoid system has been shown to be neuroprotective,1 shielding brain cells against damage and age-related changes.
Its effects in the brain also relate to many essential quality-of-life factors: mood, pain perception, cognition and memory, appetite regulation, and sleep.2,4
On a cellular level, scientists have found that the endocannabinoid system protects the brain by:1
Beyond the brain, the endocannabinoid system has a wide range of effects. It has been found to regulate:2
After discovering how diverse the effects of the endocannabinoid system are, scientists investigated how it works. They found that it contributes to all of the following:1
All of these pathways are critical in slowing the aging process and maintaining normal tissue function in various organs.
Scientists have discovered that there are ways to influence the function of the endocannabinoid system—without resorting to use of CBD (cannabidiol), THC (tetrahydrocannabinol), or other potentially psychoactive cannabinoids from cannabis.
The following compounds have been found to influence the activity of the endocannabinoid system through distinct but complementary effects.
Oleoylethanolamide is a fatty acid that is naturally produced in the body.
It is similar in structure to one of the endocannabinoid compounds.
Oleoylethanolamide’s (OEA) activity to suppress inflammation and regulate metabolism and appetite is mediated through the activity of endocannabinoid receptors but without binding to them.5-7
OEA has also been found to have neuroprotective effects and to provide support against obesity and associated metabolic abnormalities.6-8
Biochanin A is a plant flavone found in clover, peanuts, chickpeas, and soy.9
Research has found that biochanin A inhibits one of the enzymes in the endocannabinoid system called fatty acid amide hydrolase.10,11 This enzyme breaks down the endocannabinoid anandamide into inactive products.
By blocking the activity of the enzyme, biochanin A may help to support higher levels of anandamide.12
Anandamide acts as a natural pain reliever in the body, so biochanin A may be useful in treating chronic pain and other conditions.11
Anandamide, through its function as a critical molecule in the endocannabinoid system, is also believed to play important roles in regulating motivation, pleasure, and mood.3,4,13
A compound isolated from black pepper, guineensine boosts levels of both anandamide and 2-AG.14,15 It works by blocking the reuptake of these endocannabinoids after their release by cells.16
As a result, levels of anandamide and 2-AG remain higher in the body for longer. Together with biochanin A’s ability to block anandamide’s breakdown, this further boosts the beneficial effects of these endocannabinoids.
Beta-caryophyllene is found in many plants, including rosemary, clove, and black pepper.14
Scientists have discovered that this compound directly activates one of the most important endo-cannabinoid receptors, known as CB2, mimicking the activity of some endocannabinoids.14
These CB2 receptors are found throughout the body. Their activation by beta-caryophyllene has been demonstrated to:
In the last few decades, scientists have discovered that the endocannabinoid system influences the balance and function of almost all bodily systems.
In the brain, it has important beneficial effects on mood, cognition, sleep, and more.
Throughout the body, it helps maintain tissue health, prevent age-related loss of function, and lower risk for disease.
Scientists have identified four plant-derived compounds that influence the function of the endocannabinoid system: oleoylethanolamide (OEA), biochanin A, guineensine, and beta-caryophyllene.
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